Endocrine Abstracts

Introduction: Hydrocortisone (HC) is the most widely used replacement molecule in the treatment of adrenal insufficiency (AI). This substitution treatment is far from ideal especially as it is impossible to reproduce the nycthemeral cycle of cortisol with its current galenic form which has a short half-life. The aim of our work was to determine the impact of HC treatment of peripheral AI on the long-term quality of life and sleep.Patients and methods: Th...

Introduction: Diabetes mellitus (DM) and depression are two frequent health conditions. Their coexistence may represent a medical challenge for clinicians. In addition, early detection of depression can help in better management of diabetes and preventing its complications.Aim of the study: To assess depression and glycemic control among a group of patients having diabetes.Methods: A cross sectional study was conducted among diabet...

Introduction: Cushing’s disease (CD) is a rare but serious pathology in children and adolescents. It differs from adult pathology by the mode of presentation and management. We report a case of CD in a 14-year-old child whose diagnosis was confirmed only after 2 years.Observation: This was a 14-year-old female patient with a family history of consanguineous marriage and personal history of nephrotic syndrome who presented with delayed stature, delay...

Introduction: Thyroid diseases have been known to cause haemostatic changes, either tendency to bleeding or thrombosis. We report a case of a patient with primary hypothyroidism presenting with spontaneous bleeding and jugular thrombosis.Case report: An 85-year old patient with no medical history was admitted to the endocrinology department with primary auto-immune hypothyroidism. Hypothyroidism was suspected because of severe loss of weight and appetite...

Introduction: Ganglioneuroma is a rare benign tumour arising from neural crest sympathogonia. It is usually asymptomatic and non functional. An association between ganglioeneuroma and genetic or autoimmune diseases such as Addison’s disease or Mediterranean fever has never been described.Case description: We report the case of a 24-year-old woman presenting with paroxysmal abdominal pain with loss of weight and no fever. Physical examination along w...

Introduction: The otorhinolaryngologist can be confronted to multiple surprises after a thyroid surgeryCase description: We report the case of a 48 year-old woman admitted with post operative hypocalcaemia (after thyroidectomy?). The patient has a history of hypothyroidism since 5 years. She then presented a cervical swelling. The ultra-sound confirmed the presence of a suspicious thyroid nodule measuring 4 cm. A thyroidectomy was then conducted. Post op...

Leptin (LEP) gene is one of the most promising candidate genes for obesity. The aim of this study was to investigate the impact of LEP polymorphisms on obesity, anthropometric and biochemical parameters in a sample of three Tunisian consanguineous families with obesity. Seven single nucleotide polymorphisms (SNPs) in 5′ region of LEP gene were genotyped in three consanguineous families including 33 individuals. The previously reported LEP</...

Introduction: Diabetes mellitus and depression are two major public health problems which can coexist and influence each other. Identification of the predictive and associated factors with depression among diabetics can facilitate the task of clinicians.Objective: Evaluate the socio-demographic and clinical factors associated with depression among patients having diabetes mellitus (DM).Materials and methods: A cross sectional study...

Introduction: Osteoporosis and diabetes are two chronic diseases with increasing prevalences, particularly among elderly. Their coexistence results in socio-economic burdens. Clinical and paraclinical assessment for fracture risk among diabetic eldery patients are necessary to implement in clinical practice. Appropriate tools shoud to be determined and tested.Objective: To assess comorbidities and fracture risk in elderly patients having type 2 diabetes ...

Introduction: Pituitary stalk interruption syndrome (PSIS) is a rare congenital pituitary defect with an estimated incidence of 0.5 per 100,00 births. This syndrome has heterogeneous clinical presentations with varying degrees of pituitary hormones deficiencies. PSIS is commonly diagnosed during neonatal period and infancy. However, when symptoms are not evident or overlooked, the diagnosis could be delayed exposing the patient to acute, such as acute adrenal insufficiency, an...